Pta Catheter

Paclitaxel inhibits cell division and migration by preventing restenosis through the prevention of proper microtubal formation. It prevents the progression of inflammatory processes. The excretion of growth factors is a critical process, as is the initiation of cell division and the migration of smooth muscle cells, as well as the stimulation of an inflammatory reaction by injuries to the arterial wall as a result of balloon dilatation. Paclitaxel prevents the migration of vascular smooth muscle cells to the intima, which is mediated by platelet-derived growth factor (PDGF). Paclitaxel also impedes the secretion and degradation of extracellular matrix.

The proliferation of smooth muscle cells is selectively inhibited by paclitaxel. The endothelium cells exhibit a greater resistance to Paclitaxel than the smooth muscle cells as a result of the distinct affinity of the connective structure on the cell surface. The stimulation of cytokines and growth factors by paclitaxel does not affect non-proliferating cells. The freeway The smooth re-endothelialization process is improved by the paclitaxel-releasing PTA balloon dilatation catheter.Neither direct contact with shellac-coated materials nor exposure to shellac extraction products impaired the viability and function of HDMEC and hSMC in vitro.

Shellac is a natural resin that is made up of alleuritic acid and shellolic acid.

The balloon is coated with a 1:1 mixture of shellac and Paclitaxel, which is applied using a micro-pipetting procedure in a clean room under sterile conditions.