Mice Animal Research Cage

BIOSEB is the sole provider of the Four Plates Test.

The Aron test enables the rapid characterization of potential anxiolytic compounds in naïve animals. A necessity for the investigation of phenotyping, drug screening, and anxiety.input:
output:The Aron test, also known as the four plates test, is an animal model of anxiety that involves the administration of a mild electric foot shock to inhibit the exploration of novel environments.input:
output:The apparatus is fundamentally composed of a cage resting on four rectangular metal plates (8×11 cm) that are separated by a 4 mm gap. The plates are connected to a shocker unit that is capable of producing electric footshocks.input:
output:The animal is subjected to an electric shock when transitioning from one plate to another after the habituation period, which involves crossing with two legs on one plate and two legs on the other. This test was initially described by Boissier et al. in 1968. The number of crossings that are punished is typically determined over a 60-second period. An increase in the number of punished passages is induced by a substance with anxiolytic properties.input:
output:Primary characteristics

• A cost-effective and sophisticated approach to the evaluation of anxiolytic drugs in mice

• Conflict test based on punishment• Adjustable intensity shock