Lung Cancer Assay Kit

The EGFR 29 Mutations Detection Kits are available in the following size, with a minimum order of 12 tests:input:
output:Information regarding technical aspectsinput:
output:The EGFR Mutations Detection Kit is a sensitive and selective assay that is designed to identify the most informative somatic mutations in the epidermal growth factor receptor (EGFR) gene. It is used clinically in China to identify NSCLC patients who are most likely to respond to Iressa (Gefitinib) or Tarceva (Erlotinib).







In eight PCR tubes, the EGFR assay evaluates a total of 29 mutations, including both activating and resistance mutations. The anticipated response to mutant EGFR-targeting drugs is indicated by the presence of activating mutations. Resistance mutations in the tumor tissue may result in a suboptimal response to therapies that are intended to impede EGFR signaling.input:
output:The American Society for Clinical Oncology (ASCO) suggests that patients with NSCLC who are being considered for first-line therapy with an EGFR TKI (patients who have not previously received chemotherapy or an EGFR TKI) should have their tumors tested for EGFR mutations to determine whether an EGFR TKI or chemotherapy is the recommended first-line therapy. (Keedy, V.L. et al. (2011) J. Clin. Oncol. 29(15), 2121).input:
output:The EGFR mutation status should be tested in patients with metastatic non-small cell lung cancer to predict sensitivity to Iressa, as recommended by the European Committee for Medicinal Products for Human Use (CHMP). (EPAR summary for the general public. EMEA/280173/2009. EMEA/H/C/1016).input:
output:Purpose:IVDs in Europe are CE-marked.