Animal Research Analgesiometer

In models of peripheral pain sensitization for mice, the “jump to escape” test is a novel setup that enables the differentiation of thermal allodynia from hyperalgesia by evaluating the escaping behavior of mice as they experience a ramp of cold and hot temperatures over an aluminum plate. A necessity for your research on analgesia, particularly in order to assess the pharmacological effects of cancer treatment, such as chemotherapy-induced neuropathy.

Following the publications of I. Yalcin et al. (The Journal of Pain, 2009) and complementary works from the team of Dr. Bourinet (EMBO J.Descoeur et al, 2011) regarding hypersensitivity to cold stimulus, BIOSEB has developed an entirely new set-up for the evaluation of the escaping behavior of mice undergoing a ramp of temperature (cold and hot) over an aluminum plate.

The entire instrument is constructed around a metal plate that can be heated to 65°C and cooled to -3°C (with an ambient temperature between 20°C and 25°C). This hardware is based on our popular Hot and Cold Plate hardware, which has already opened new investigation fields for your analgesia and nociception research. A special back lighting plate and an HD camera that is sensitive to the backlight wavelength are positioned in front of the Hot and Cold Plate to complete the classical setting.input:
output:The test has been primarily employed to assess the pharmacological effects of cancer treatment on mice’s cold sensitivity.